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Oneof the earliest terms used to classify cognitive changesin the elderly is benign senescent forgetfulness, introducedin 1962 by Kral, who believed it represented a variant ofnormal aging instead of being a predementia term entity.The Clinical Dementia Rating (CDR) scale, which wasreported in 1982, included the term questionable demen-tia, or CDR 0.5 (CDR 0 was equivalent to normal cogni-tion and CDR 1 equated to mild dementia in this scale;Hughes et al., 1982; Morris, 1993). Additionally,current guidelines suggest that oral ?-blocker therapy shouldbe initiated within the first 24 hours after ACS, unless there is acontraindication (class I, level B). Restoringthe cells to normoxic conditions results in a return to basal expression levels after1 h [ 17]. One proposed change is touse risk extrapolation models that make fewer assumptionsabout the shape of the dose–response curve (e.g., the BMDand margin-of-exposure method)

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The results of this study reported asignificant reduction in the composite end point of death fromcoronary heart disease, nonfatal myocardial infarction, andhospital readmission for cardiac chest pain during a follow-up ofabout 18 months.

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